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Anti-Helicobacter pylori Antibody

品牌：Antibodies

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规格：100µg

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Anti-Helicobacter pylori Antibody

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Overview

Name:	Anti-Helicobacter pylori Antibody See all Helicobacter pylori primary antibodies
Description:	Rabbit polyclonal antibody to Helicobacter pylori
Applications:	CM, ELISA, ICC, IF, IP, IHC, WB
Dilutions:	ELISA: 1:5,000; Immunocytochemistry: 1:200; Immunofluorescence: 1:300; Immunohistochemistry: 1:200; Immunoprecipitation: 1:150; Western Blot: 1:500
Reactivity:	Helicobacter pylori
Immunogen:	Heat killed and denatured Helicobacter pylori extracts
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Concentration:	0.80-1.35 μg/μl in antibody stabilization buffer
Storage:	-20?C for long term storage

Target

Function:	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Tissue Specificity:	Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
Involvement in Disease:	Glaucoma 1, open angle, E: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Glaucoma, normal pressure: A primary glaucoma characterized by intraocular pression consistently within the statistically normal population range. Amyotrophic lateral sclerosis 12: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Post-Translational Modification:	Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection. Phosphorylation is induced by phorbol esters and decreases its half-time.
Cellular Location:	Cytoplasm > Perinuclear region. Golgi apparatus. Golgi apparatus > trans-Golgi network. Cytoplasmic vesicle > Autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy.
Synonyms:	H. pylori Antibody Helicobacter pylori Antibody
Information:	Target information shown above is from the UniProt Consortium.