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Anti-Heat shock 70 kDa protein 6 Antibody

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Anti-Heat shock 70 kDa protein 6 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Heat shock 70 kDa protein 6 Antibody

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Overview

Name:	Anti-Heat shock 70 kDa protein 6 Antibody See all Heat shock 70 kDa protein 6 primary antibodies
Description:	Rabbit polyclonal antibody to Heat shock 70 kDa protein 6
Specificity:	The antibody detects endogenous level of total Heat shock 70 kDa protein 6 polyclonal antibody.
Applications:	WB
Reactivity:	Human
Immunogen:	Recombinant human Heat shock 70 kDa protein 6 protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration:	1.0mg / mL
Formulation:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage:	Store at -20˚C

Target

Function:	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).
Sequence Similarities:	Belongs to the heat shock protein 70 family.
Database Links:	Entrez Gene: 3310 Human Omim: 140555 Human SwissProt: P17066 Human Unigene: 654614 Human
Synonyms:	Heat shock 70 kDa protein 6 Antibody Heat shock 70 kDa protein B' Antibody Heat shock 70 kDa protein B'' Antibody heat shock 70kD protein 6 (HSP70B') Antibody Heat shock 70kDa protein 6 Antibody HSP70B' Antibody HSP70B-Prime Antibody HSP76_HUMAN Antibody HSPA6 Antibody OTTHUMP00000032372 Antibody
Information:	Target information shown above is from the UniProt Consortium.