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Anti-HDAC8 Antibody

品牌：Antibodies

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规格：100µl

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Anti-HDAC8 Antibody

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Overview

Name:	Anti-HDAC8 Antibody See all HDAC8 primary antibodies
Description:	Rabbit polyclonal antibody to HDAC8
Specificity:	The antibody detects endogenous level of total HDAC8 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human HDAC8.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
Tissue Specificity:	Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
Involvement in Disease:	Cornelia de Lange syndrome 5: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. Wilson-Turner X-linked mental retardation syndrome: A neurologic disorder characterized by severe intellectual disability, dysmorphic facial features, hypogonadism, short stature, and truncal obesity. Affected females have a milder phenotype than affected males.
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 1 subfamily.
Post-Translational Modification:	Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.
Cellular Location:	Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Database Links:	Entrez Gene: 55869?Human Entrez Gene: 70315?Mouse Entrez Gene: 363481?Rat Omim: 300269?Human SwissProt: Q9BY41?Human SwissProt: Q8VH37?Mouse SwissProt: B1WC68?Rat Unigene: 310536?Human Unigene: 328128?Mouse Unigene: 208476?Rat
Synonyms:	CDA07 Antibody CDLS5 Antibody HD 8 Antibody HD8 Antibody HDAC 8 Antibody HDAC8 Antibody HDAC8_HUMAN Antibody HDACL 1 Antibody HDACL1 Antibody Histone deacetylase 8 Antibody Histone deacetylase like 1 Antibody MRXS6 Antibody RPD 3 Antibody RPD3 Antibody WTS Antibody
Information:	Target information shown above is from the UniProt Consortium.