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Anti-HDAC6 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-HDAC6 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-HDAC6 Antibody See all HDAC6 primary antibodies
Description:	Goat polyclonal antibody to HDAC6.
Applications:	ELISA, WB
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to Human HDAC6 (C terminal).
Sequence:	C-AHQNKFGEDMPHPH
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
Tissue Specificity:	Expressed in neurons of the cortex. Expressed in Purkinje cells. Detected in keratinocytes (at protein level).
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 2 subfamily.
Post-Translational Modification:	Phosphorylated by AURKA.
Cellular Location:	Nucleus. Cytoplasm. Perikaryon. Cell projection > Dendrite. Cell projection > Axon. It is mainly cytoplasmic, where it is associated with microtubules.
Database Links:	Entrez Gene: 10013 Human Entrez Gene: 15185 Mouse Omim: 300272 Human SwissProt: Q9UBN7 Human SwissProt: Q9Z2V5 Mouse Unigene: 6764 Human Unigene: 29854 Mouse
Synonyms:	CPBHM Antibody FLJ16239 Antibody HD 6 Antibody HD6 Antibody HDAC 6 Antibody HDAC6 Antibody HDAC6_HUMAN Antibody Histone deacetylase 6 Antibody Histone deacetylase 6 (HD6) Antibody JM 21 Antibody JM21 Antibody KIAA0901 Antibody OTTHUMP00000032398 Antibody OTTHUMP00000197663 Antibody PPP1R90 Antibody Protein phosphatase 1 regulatory subunit 90 Antibody
Information:	Target information shown above is from the UniProt Consortium.