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Anti-SENP6 Antibody

品牌：Antibodies

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规格：100µl

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Anti-SENP6 Antibody

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Overview

Name:	Anti-SENP6 Antibody See all SENP6 primary antibodies
Description:	Rabbit polyclonal antibody to SENP6
Specificity:	The antibody detects endogenous levels of total SENP6 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide of human SENP6
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.2mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Tissue Specificity:	Highly expressed in reproductive organs, such as testis, ovary and prostate.
Sequence Similarities:	Belongs to the peptidase C48 family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 26054?Human Omim: 605003?Human SwissProt: Q9GZR1?Human Unigene: 485784?Human
Synonyms:	2810017C20Rik Antibody FLJ11355 Antibody FLJ11887 Antibody KIAA0389 Antibody KIAA0797 Antibody SENP 6 Antibody SENP6 Antibody SENP6_HUMAN Antibody Sentrin specific protease 6 Antibody Sentrin-specific protease 6 Antibody Sentrin/SUMO specific protease SENP6 Antibody Sentrin/SUMO-specific protease SENP6 Antibody SSP 1 Antibody SSP1 Antibody SUMO 1 specific protease Antibody SUMO 1 specific protease 1 Antibody SUMO-1-specific protease 1 Antibody SUMO1 specific protease Antibody SUMO1 specific protease 1 Antibody SUMO1/sentrin specific peptidase 6 Antibody SUSP 1 Antibody SUSP1 Antibody
Information:	Target information shown above is from the UniProt Consortium.