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Anti-SENP3 (Y24) Antibody

品牌：Antibodies

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规格：50µl

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Anti-SENP3 (Y24) Antibody

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Overview

Name:	Anti-SENP3 (Y24) Antibody See all SENP3 primary antibodies
Description:	Rabbit polyclonal antibody to SENP3 (Y24)
Specificity:	SENP3 (Y24) pAb detects endogenous levels of SENP3 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to the N-terminual of Human SENP3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 65 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Sequence Similarities:	Belongs to the peptidase C48 family.
Cellular Location:	Nucleus > Nucleolus. Nucleus > Nucleoplasm. Cytoplasm. Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).
Database Links:	Entrez Gene: 26168?Human Entrez Gene: 80886?Mouse Entrez Gene: 303245?Rat Omim: 612844?Human SwissProt: Q9H4L4?Human SwissProt: Q9EP97?Mouse Unigene: 513926?Human Unigene: 733104?Human Unigene: 284592?Mouse Unigene: 422171?Mouse Unigene: 24219?Rat
Synonyms:	SENP3 Antibody SENP3_HUMAN Antibody Sentrin / SUMO specific protease 3 Antibody Sentrin specific protease 3 Antibody Sentrin-specific protease 3 Antibody Sentrin/SUMO-specific protease SENP3 Antibody SMT3IP1 Antibody SSP3 Antibody SUMO 1 specific protease 3 Antibody SUMO-1-specific protease 3 Antibody SUMO1 specific protease 3 Antibody SUMO1/sentrin/SMT3 specific peptidase 3 Antibody SUSP3 Antibody
Information:	Target information shown above is from the UniProt Consortium.