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Anti-RPA32 / RPA2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-RPA32 / RPA2 Antibody

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Overview

Name:	Anti-RPA32 / RPA2 Antibody See all RPA32 primary antibodies
Description:	Mouse monoclonal antibody to RPA32 / RPA2
Specificity:	This antibody detects endogenous levels of RPA32 / RPA2 and does not cross-react with related proteins.
Applications:	WB, IP, ICC
Reactivity:	Human
Immunogen:	Purified recombinant human RPA32 / RPA2 protein fragments expressed in E.coli.
Host:	Mouse
Clonality:	Monoclonal
Isotype:	IgG2b
Conjugate:	Unconjugated
Purification:	Affinity purified
Formulation:	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage:	store at -20˚C

Target

Function:	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Sequence Similarities:	Belongs to the replication factor A protein 2 family.
Post-Translational Modification:	Differentially phosphorylated throughout the cell cycle, becoming phosphorylated at the G1-S transition and dephosphorylated in late mitosis. Mainly phosphorylated at Ser-23 and Ser-29, by cyclin A-CDK2 and cyclin B-CDK1, respectively during DNA replication and mitosis. Dephosphorylation may require the serine/threonine-protein phosphatase 4. Phosphorylation at Ser-23 and Ser-29 is a prerequisite for further phosphorylation. Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage. Hyperphosphorylation is mediated by ATM, ATR and PRKDC. Primarily recruited to DNA repair nuclear foci as a hypophosphorylated form it undergoes subsequent hyperphosphorylation, catalyzed by ATR. Hyperphosphorylation is required for RAD51 recruitment to chromatin and efficient DNA repair. Phosphorylation at Thr-21 depends upon RFWD3 presence.
Cellular Location:	Nucleus. Nucleus > PML body. Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Database Links:	Entrez Gene: 6118 Human Omim: 179836 Human SwissProt: P15927 Human Unigene: 703070 Human Unigene: 79411 Human
Synonyms:	60S acidic ribosomal protein P1 Antibody AA409079 Antibody AI325195 Antibody AU020965 Antibody ik:tdsubc_2g1 Antibody M(2)21C Antibody MGC137236 Antibody OTTHUMP00000004008 Antibody p32 Antibody p34 Antibody RCJMB04_6d17 replication protein A2, 32kDa Antibody REPA2 Antibody Replication factor A protein 2 Antibody Replication protein A Antibody Replication protein A 32 kDa subunit Antibody Replication protein A 32kDa subunit Antibody Replication protein A 34 kDa subunit Antibody Replication protein A2 Antibody Replication Protein A2 (32kDa) Antibody Replication protein A2, 32kDa Antibody RF-A protein 2 Antibody Rf-A2 Antibody RFA Antibody RFA2_HUMAN Antibody RP-A p32 Antibody RP-A p34 Antibody RP21C Antibody RPA Antibody RPA 2 Antibody RPA 32 Antibody Rpa2 Antibody RPA32 Antibody RPA32/RPA2 Antibody RPA34 Antibody RpLP1 Antibody RpP2 Antibody xx:tdsubc_2g1 Antibody zgc:109822 Antibody
Information:	Target information shown above is from the UniProt Consortium.