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Anti-RORC Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-RORC Antibody

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Overview

Name:	Anti-RORC Antibody See all ROR gamma primary antibodies
Description:	Goat polyclonal antibody to RORC.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human RORC (internal region).
Sequence:	CHLEYSPERGKAE
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376).
Tissue Specificity:	Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Involvement in Disease:	Immunodeficiency 42: An autosomal recessive primary immunodeficiency characterized by increased susceptibility to concomitant candidiasis and mycobacteriosis. Candidiasis is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida. Mycobacteriosis is characterized by infections caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. IMD42 patients vaccinated with BCG are particularly at risk for developing disseminated mycobacterial infections.
Sequence Similarities:	Belongs to the nuclear hormone receptor family. NR1 subfamily.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 6097 Human Omim: 602943 Human SwissProt: P51449 Human Unigene: 256022 Human Unigene: 607993 Human
Synonyms:	IMD42 Antibody MGC129539 Antibody NR1F3 Antibody Nuclear receptor ROR gamma Antibody Nuclear receptor ROR-gamma Antibody Nuclear receptor RZR gamma Antibody Nuclear receptor RZR-gamma Antibody Nuclear receptor subfamily 1 group F member 3 Antibody RAR related orphan nuclear receptor variant 2 Antibody RAR related orphan receptor C Antibody RAR related orphan receptor C, isoform a Antibody RAR related orphan receptor gamma Antibody RAR-related orphan receptor C Antibody Retinoic acid binding receptor gamma Antibody Retinoid related orphan receptor gamma Antibody Retinoid-related orphan receptor-gamma Antibody ROR gamma Antibody Rorc Antibody RORG Antibody RORG_HUMAN Antibody RZR GAMMA Antibody RZRG Antibody TOR Antibody
Information:	Target information shown above is from the UniProt Consortium.