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Anti-ROCK1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ROCK1 Antibody

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Overview

Name:	Anti-ROCK1 Antibody See all ROCK1 primary antibodies
Description:	Rabbit polyclonal antibody to ROCK1
Applications:	WB, IHC, IF
Dilutions:	Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:500 Immunofluorescence: 1:100-1:200
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 107 and 381 of ROCK1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Predicted MW:	158kd
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
Tissue Specificity:	Detected in blood platelets.
Sequence Similarities:	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Post-Translational Modification:	Autophosphorylated on serine and threonine residues.
Cellular Location:	Cytoplasm. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Golgi apparatus membrane. Cell projection > Bleb. Cytoplasm > Cytoskeleton. Cell membrane. Cell projection > Lamellipodium. Cell projection > Ruffle. Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi membranes.
Database Links:	Entrez Gene: 6093?Human Omim: 601702?Human SwissProt: Q13464?Human Unigene: 306307?Human
Synonyms:	coiled-coil-containing protein kinase 1 Antibody coiled-coil-containing protein kinase I Antibody coiled-coil-containing protein kinase 1 Antibody coiled-coil-containing protein kinase I Antibody MGC131603 Antibody MGC43611 Antibody p160 Rhoassociated coiled coil-forming protein kinase Antibody p160 ROCK-1 Antibody p160 ROCK1 Antibody p160ROCK Antibody PRO0435 Antibody Renal carcinoma antigen NY REN 35 Antibody Renal carcinoma antigen NY-REN-35 Antibody Rho associated coiled coil containing protein kinase 1 Antibody Rho associated protein kinase 1 Antibody Rho kinase Antibody Rho-alpha kinase Antibody Rho-associated Antibody Rho-associated protein kinase 1 Antibody ROCK I Antibody ROCK-I Antibody ROCK1 Antibody ROCK1_HUMAN Antibody Rok Antibody rokalpha Antibody
Information:	Target information shown above is from the UniProt Consortium.