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Anti-RICTOR Antibody

品牌：Antibodies

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规格：100µl

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Anti-RICTOR Antibody

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Overview

Name:	Anti-RICTOR Antibody See all RICTOR primary antibodies
Description:	Rabbit polyclonal antibody to RICTOR
Applications:	WB, IHC, IF
Reactivity:	Human
Immunogen:	Synthetic peptide contain a sequence corresponding to a region within amino acids 1648 and 1708 of RICTOR
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Sequence Similarities:	Belongs to the RICTOR family.
Post-Translational Modification:	Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
Database Links:	Entrez Gene: 253260?Human Omim: 609022?Human SwissProt: Q6R327?Human Unigene: 407926?Human
Synonyms:	AVO3 Antibody AVO3 homolog Antibody DKFZp686B11164 Antibody hAVO3 Antibody KIAA1999 Antibody Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) Antibody mAVO3 Antibody MGC39830 Antibody PIA Antibody Pianissimo Antibody Rapamycin insensitive companion of mTOR Antibody Rapamycin-insensitive companion of mTOR Antibody RICTOR Antibody RICTR Antibody RICTR_HUMAN Antibody RPTOR independent companion of MTOR complex 2 Antibody TORC2 specific protein AVO3 Antibody
Information:	Target information shown above is from the UniProt Consortium.