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Anti-RCC1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-RCC1 Antibody

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Overview

Name:	Anti-RCC1 Antibody See all RCC1 primary antibodies
Description:	Rabbit polyclonal antibody to RCC1
Specificity:	The antibody detects endogenous levels of total RCC1 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthesized peptide derived from human RCC1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
Post-Translational Modification:	N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.
Cellular Location:	Nucleus. Cytoplasm. Becomes dispersed throughout the cytoplasm during mitosis.
Database Links:	Entrez Gene: 1104?Human Omim: 179710?Human SwissProt: P18754?Human Unigene: 469723?Human
Synonyms:	Cell cycle regulatory protein Antibody CHC 1 Antibody CHC1 Antibody Chromosome condensation 1 Antibody Chromosome condensation protein 1 Antibody Guanine nucleotide releasing protein Antibody HERC2 Antibody Ran GEF Antibody RanGEF Antibody RCC 1 Antibody RCC1 Antibody RCC1 I Antibody RCC1_HUMAN Antibody Regulator of chromosome condensation Antibody Regulator of chromosome condensation 1 Antibody SHEP1 Antibody SNHG3 RCC1 Antibody SNHG3 RCC1 readthrough transcript Antibody
Information:	Target information shown above is from the UniProt Consortium.