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Anti-RBX1 Antibody

品牌：Antibodies

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规格：100µl

货期：

应用：

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Anti-RBX1 Antibody

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Overview

Name:	Anti-RBX1 Antibody See all RBX1 primary antibodies
Description:	Rabbit polyclonal antibody to RBX1
Specificity:	The antibody detects endogenous levels of total RBX1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human RBX1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the RING-box family.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 9978?Human Entrez Gene: 56438?Mouse Omim: 603814?Human SwissProt: P62877?Human SwissProt: P62878?Mouse Unigene: 474949?Human Unigene: 29405?Mouse
Synonyms:	BA554C12.1 Antibody E3 ubiquitin-protein ligase RBX1 Antibody FLJ60363 Antibody MGC13357 Antibody MGC1481 Antibody OTTHUMP00000028983 Antibody Protein ZYP Antibody Rbx 1 Antibody Rbx1 Antibody RBX1_HUMAN Antibody Regulator of cullins 1 Antibody Ring box 1 Antibody Ring box 1 E3 ubiquitin protein ligase Antibody RING box protein 1 Antibody RING finger protein Antibody RING finger protein 75 Antibody RING-box protein 1 Antibody Ringbox protein 1 Antibody RNF 75 Antibody RNF75 Antibody ROC 1 Antibody ROC1 Antibody ZYP protein Antibody
Information:	Target information shown above is from the UniProt Consortium.