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Anti-RAN Antibody

品牌：Antibodies

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规格：50µl

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Anti-RAN Antibody

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Overview

Name:	Anti-RAN Antibody See all RAN primary antibodies
Description:	Rabbit polyclonal antibody to RAN
Specificity:	RAN pAb detects endogenous levels of RAN protein.
Applications:	WB, IHC, IF, IP, RIP
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human RAN.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 26 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport.
Tissue Specificity:	Expressed in a variety of tissues.
Sequence Similarities:	Belongs to the small GTPase superfamily. Ran family.
Cellular Location:	Nucleus. Nucleus envelope. Cytoplasm. Melanosome. Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Database Links:	Entrez Gene: 5901?Human Entrez Gene: 100045999?Mouse Entrez Gene: 19384?Mouse Entrez Gene: 84509?Rat Omim: 601179?Human SwissProt: P62826?Human SwissProt: P62827?Mouse SwissProt: P62828?Rat Unigene: 10842?Human Unigene: 297440?Mouse Unigene: 386831?Mouse Unigene: 107698?Rat
Synonyms:	Androgen receptor associated protein 24 Antibody Androgen receptor-associated protein 24 Antibody ARA 24 Antibody ARA24 Antibody Gsp1 Antibody GTP binding nuclear protein RAN Antibody GTP-binding nuclear protein Ran Antibody GTPase Ran Antibody Guanosine triphosphatase Ran Antibody LPS Antibody Member RAS oncogene family Antibody OK/SW-cl.81 Antibody Ran Antibody RAN member RAS oncogene family Antibody RanGTPase Antibody RAN_HUMAN Antibody Ras like protein TC4 Antibody Ras related nuclear protein Antibody Ras-like protein TC4 Antibody Ras-related nuclear protein Antibody RASL2 8 Antibody TC 4 Antibody TC4 Antibody
Information:	Target information shown above is from the UniProt Consortium.