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Anti-Rad51 (L302) Antibody

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规格：50µl

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Anti-Rad51 (L302) Antibody

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Overview

Name:	Anti-Rad51 (L302) Antibody See all Rad51 primary antibodies
Description:	Rabbit polyclonal antibody to Rad51 (L302)
Specificity:	Rad51 (L302) pAb detects endogenous levels of Rad51 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide, corresponding to amino acids 280-330 of Human Rad51.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 42 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
Tissue Specificity:	Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
Involvement in Disease:	Breast cancer: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Mirror movements 2: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.
Sequence Similarities:	Belongs to the RecA family. RAD51 subfamily.
Post-Translational Modification:	Ubiquitinated by the SCF(FBXO18) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA.
Cellular Location:	Nucleus. Cytoplasm. Cytoplasm > Perinuclear region. Mitochondrion matrix. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner.
Database Links:	Entrez Gene: 5888?Human Entrez Gene: 19361?Mouse Omim: 179617?Human SwissProt: Q06609?Human SwissProt: Q08297?Mouse Unigene: 631709?Human Unigene: 330492?Mouse
Synonyms:	BRCA1/BRCA2 containing complex, subunit 5 Antibody BRCC 5 Antibody BRCC5 Antibody DNA repair protein RAD51 homolog 1 Antibody DNA repair protein rhp51 Antibody FANCR Antibody hRAD51 Antibody HsRAD51 Antibody HsT16930 Antibody MRMV2 Antibody Rad 51 Antibody Rad51 Antibody RAD51 homolog Antibody RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) Antibody RAD51 homolog A Antibody RAD51 recombinase Antibody RAD51, S. cerevisiae, homolog of Antibody RAD51A Antibody RAD51_HUMAN Antibody RECA Antibody RecA like protein Antibody RecA, E. coli, homolog of Antibody Recombination protein A Antibody
Information:	Target information shown above is from the UniProt Consortium.