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Anti-RAC1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-RAC1 Antibody

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Overview

Name:	Anti-RAC1 Antibody See all RAC1 primary antibodies
Description:	Rabbit polyclonal antibody to RAC1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human RAC1.
Protein Length:	192
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.
Tissue Specificity:	Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
Sequence Similarities:	Belongs to the small GTPase superfamily. Rho family.
Post-Translational Modification:	(Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
Cellular Location:	Cell membrane. Melanosome. Cytoplasm. Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts (By similarity).
Database Links:	Entrez Gene: 5879?Human Entrez Gene: 19353?Mouse Entrez Gene: 363875?Rat Omim: 602048?Human SwissProt: P63000?Human SwissProt: P63001?Mouse SwissProt: Q6RUV5?Rat Unigene: 413812?Human Unigene: 292510?Mouse Unigene: 342177?Mouse Unigene: 29157?Rat
Synonyms:	Cell migration inducing gene 5 protein Antibody Cell migration-inducing gene 5 protein Antibody MGC111543 Antibody MIG5 Antibody Migration inducing gene 5 Antibody Migration inducing protein 5 Antibody p21 Rac1 Antibody p21-Rac1 Antibody Rac 1 Antibody Rac1 Antibody RAC1_HUMAN Antibody Ras like protein TC25 Antibody Ras related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Antibody Ras-like protein TC25 Antibody Ras-related C3 botulinum toxin substrate 1 Antibody Rho family small GTP binding protein Rac1 Antibody TC 25 Antibody TC25 Antibody
Information:	Target information shown above is from the UniProt Consortium.