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Anti-RAB5A Antibody

品牌：Antibodies

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规格：50µl

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Anti-RAB5A Antibody

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Overview

Name:	Anti-RAB5A Antibody See all RAB5A primary antibodies
Description:	Rabbit monoclonal antibody to RAB5A
Specificity:	This antibody detects endogenous levels of RAB5A and does not cross-react with related proteins.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 24 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Sequence Similarities:	Belongs to the small GTPase superfamily. Rab family.
Cellular Location:	Cell membrane. Early endosome membrane. Melanosome. Cytoplasmic vesicle. Cell projection > Ruffle. Membrane. Cytoplasm > Cytosol. Cytoplasmic vesicle > Phagosome membrane. Endosome membrane. Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable).
Database Links:	Entrez Gene: 5868?Human Entrez Gene: 271457?Mouse Entrez Gene: 64633?Rat Omim: 179512?Human SwissProt: P20339?Human SwissProt: Q9CQD1?Mouse SwissProt: M0RC99?Rat Unigene: 475663?Human Unigene: 329123?Mouse Unigene: 44477?Rat
Synonyms:	RAB 5 Antibody RAB 5A Antibody Rab5 Antibody RAB5A Antibody RAB5A member RAS oncogene family Antibody RAB5A_HUMAN Antibody RAS associated protein RAB5A Antibody Ras related protein Rab 5A Antibody Ras-related protein Rab-5A Antibody
Information:	Target information shown above is from the UniProt Consortium.