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Anti-ATG3 Antibody

品牌：Antibodies

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规格：50µl

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Anti-ATG3 Antibody

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Overview

Name:	Anti-ATG3 Antibody See all ATG3 primary antibodies
Description:	Rabbit polyclonal antibody to ATG3.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human ATG3.
Protein Length:	314
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Tissue Specificity:	Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.
Sequence Similarities:	Belongs to the ATG3 family.
Post-Translational Modification:	Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 64422?Human Entrez Gene: 67841?Mouse Entrez Gene: 171415?Rat Omim: 609606?Human SwissProt: Q9NT62?Human SwissProt: Q9CPX6?Mouse SwissProt: Q6AZ50?Rat Unigene: 477126?Human Unigene: 41775?Mouse Unigene: 3084?Rat
Synonyms:	2610016C12Rik Antibody Apg 3 Antibody Apg3 Antibody APG3 autophagy 3 like Antibody APG3 like Antibody APG3, S. cerevisiae, homolog of Antibody APG3-like Antibody APG3L Antibody Apg3p Antibody ATG 3 Antibody ATG3 Antibody ATG3 autophagy related 3 homolog Antibody ATG3 autophagy related 3 homolog (S. cerevisiae) Antibody ATG3_HUMAN Antibody Autophagy 3, S. cerevisiae, homolog of Antibody Autophagy Apg3p/Aut1p like Antibody autophagy related 3 Antibody Autophagy related protein 3 Antibody Autophagy-related protein 3 Antibody DKFZp564M1178 Antibody FLJ22125 Antibody hApg3 Antibody MGC15201 Antibody OTTHUMP00000214547 Antibody OTTHUMP00000214548 Antibody PC3 96 Antibody Protein PC3-96 Antibody Ubiquitin-like-conjugating enzyme ATG3 Antibody
Information:	Target information shown above is from the UniProt Consortium.