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Anti-ATF4 (R239) Antibody

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规格：50µl

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Anti-ATF4 (R239) Antibody

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Overview

Name:	Anti-ATF4 (R239) Antibody See all ATF4 primary antibodies
Description:	Rabbit polyclonal antibody to ATF4 (R239)
Specificity:	ATF4 (R239) pAb detects endogenous levels of ATF4 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 200-250 of Human ATF4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 42 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.
Cellular Location:	Cytoplasm. Cell membrane. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783).
Database Links:	Entrez Gene: 468?Human Entrez Gene: 11911?Mouse Entrez Gene: 79255?Rat Omim: 604064?Human SwissProt: P18848?Human SwissProt: Q06507?Mouse SwissProt: Q9ES19?Rat Unigene: 496487?Human Unigene: 641?Mouse Unigene: 2423?Rat
Synonyms:	Activating transcription factor 4 Antibody ATF 4 Antibody ATF-4 Antibody ATF4 Antibody ATF4 protein Antibody ATF4_HUMAN Antibody cAMP-dependent transcription factor ATF-4 Antibody cAMP-responsive element-binding protein 2 Antibody CREB 2 Antibody CREB-2 Antibody CREB2 Antibody Cyclic AMP dependent transcription factor ATF 4 Antibody Cyclic AMP response element binding protein 2 Antibody Cyclic AMP-dependent transcription factor ATF-4 Antibody Cyclic AMP-responsive element-binding protein 2 Antibody DNA binding protein TAXREB67 Antibody DNA-binding protein TAXREB67 Antibody Tax Responsive Enhancer Element B67 Antibody Tax-responsive enhancer element-binding protein 67 Antibody TaxREB67 Antibody TXREB Antibody
Information:	Target information shown above is from the UniProt Consortium.