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Anti-ARL2 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-ARL2 Antibody

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Overview

Name:	Anti-ARL2 Antibody See all ARL2 primary antibodies
Description:	Goat polyclonal antibody to ARL2.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human ARL2 (C terminal).
Sequence:	C-LDDISSRIFTAD
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.
Sequence Similarities:	Belongs to the small GTPase superfamily. Arf family.
Post-Translational Modification:	Not N-myristoylated.
Cellular Location:	Mitochondrion intermembrane space. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Nucleus. Cytoplasm. The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.
Database Links:	Entrez Gene: 402 Human Omim: 601175 Human SwissProt: P36404 Human Unigene: 502836 Human
Synonyms:	ADP ribosylation factor like 2 Antibody ADP-ribosylation factor-like protein 2 Antibody ARFL2 Antibody Arl184 Antibody ARL2 Antibody ARL2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.