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Anti-ARC (E194) Antibody

品牌：Antibodies

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规格：50µl

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Anti-ARC (E194) Antibody

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Overview

Name:	Anti-ARC (E194) Antibody See all ARC primary antibodies
Description:	Rabbit polyclonal antibody to ARC (E194)
Specificity:	ARC (E194) pAb detects endogenous levels of ARC protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 161-210 of Human ARC.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 24 or 28 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Isoform 1: May be involved in RNA splicing.
Tissue Specificity:	Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas.
Involvement in Disease:	Myoclonus, familial cortical: An autosomal dominant neurologic condition characterized by ***** onset of cortical myoclonus manifest as involuntary jerks or movements affecting the face and limbs. Affected individuals can also experience falls without seizure activity or loss of consciousness.
Post-Translational Modification:	Phosphorylation at Thr-149 is required for its antiapoptotic effect by blocking death-inducing signaling complex death-inducing signaling complex (DISC) activity through the control of interaction with CASP8. Phosphorylation at Thr-149 results in translocation to mithochondria and this translocation enables the binding to CASP8. Dephosphorylated at Thr-149 by calcineurin; doesn't inhibit the association between FADD and CASP8 and the consequent apoptosis.
Cellular Location:	Nucleus > Nucleolus. The SR-rich C-terminus mediates nuclear localization.
Database Links:	Entrez Gene: 23237?Human Entrez Gene: 11838?Mouse Entrez Gene: 54323?Rat Omim: 612461?Human SwissProt: Q7LC44?Human SwissProt: Q9WV31?Mouse SwissProt: Q63053?Rat Unigene: 40888?Human Unigene: 741621?Human Unigene: 25405?Mouse Unigene: 10086?Rat
Synonyms:	activity regulated cytoskeleton associated protein Antibody activity regulated gene 3.1 protein homolog Antibody Activity-regulated cytoskeleton-associated protein Antibody Activity-regulated gene 3.1 protein homolog Antibody Arc Antibody ARC/ARG3.1 Antibody ARC_HUMAN Antibody Arg3.1 Antibody
Information:	Target information shown above is from the UniProt Consortium.