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Anti-APLP1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-APLP1 Antibody

商品详情参考文献相关资料

Name:	Anti-APLP1 Antibody See all APLP1 primary antibodies
Description:	Rabbit polyclonal antibody to APLP1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:20 - 1:50.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human APLP1.
Protein Length:	650
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Tissue Specificity:	Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
Sequence Similarities:	Belongs to the APP family.
Post-Translational Modification:	Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 333?Human Entrez Gene: 11803?Mouse Entrez Gene: 502317?Rat Omim: 104775?Human SwissProt: P51693?Human SwissProt: Q03157?Mouse Unigene: 74565?Human Unigene: 2381?Mouse
Synonyms:	AMYLOID BETA A4 PRECURSOR-LIKE PROTEIN 1 Antibody AMYLOID PRECURSOR-LIKE PROTEIN Antibody Amyloid-like protein 1 precursor Antibody APLP Antibody APLP 1 Antibody APLP-1 Antibody APLP1 Antibody APLP1_HUMAN Antibody C30 Antibody
Information:	Target information shown above is from the UniProt Consortium.