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Anti-ANGPTL4 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ANGPTL4 Antibody

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Overview

Name:	Anti-ANGPTL4 Antibody See all ANGPTL4 primary antibodies
Description:	Rabbit polyclonal antibody to ANGPTL4
Specificity:	The antibody detects endogenous level of total ANGPTL4 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human ANGPTL4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).
Tissue Specificity:	Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Post-Translational Modification:	N-glycosylated.
Cellular Location:	Secreted. Secreted > Extracellular space > Extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity).
Database Links:	Entrez Gene: 51129?Human Entrez Gene: 57875?Mouse Entrez Gene: 362850?Rat Omim: 605910?Human SwissProt: Q9BY76?Human SwissProt: Q9Z1P8?Mouse SwissProt: Q6TMA8?Rat Unigene: 9613?Human Unigene: 196189?Mouse Unigene: 119611?Rat
Synonyms:	Angiopoietin like 4 Antibody Angiopoietin related protein 4 Antibody Angiopoietin-like 4 Antibody Angiopoietin-like protein 4 Antibody Angiopoietin-related protein 4 Antibody ANGL4_HUMAN Antibody ANGPT L2 Antibody ANGPT L4 Antibody ANGPTL2 Antibody Angptl4 Antibody ARP4 Antibody Fasting induced adipose factor Antibody FIAF Antibody HARP Antibody Hepatic angiopoietin related protein Antibody Hepatic fibrinogen/angiopoietin related protein Antibody Hepatic fibrinogen/angiopoietin-related protein Antibody HFARP Antibody NL2 Antibody Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein Antibody PGAR Antibody pp1158 Antibody PPARG angiopoietin related protein Antibody PSEC0166 Antibody TGQTL Antibody UNQ171 Antibody Weakly similar to angiopoietin 1 [H.sapiens] Antibody
Information:	Target information shown above is from the UniProt Consortium.