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Anti-ALK (Phospho-Tyr1604) Antibody

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规格：50µl

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Anti-ALK (Phospho-Tyr1604) Antibody

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Overview

Name:	Anti-ALK (Phospho-Tyr1604) Antibody See all ALK primary antibodies
Description:	Rabbit polyclonal antibody to ALK (Phospho-Tyr1604)
Specificity:	The antibody detects endogenous levels of ALK only when phosphorylated at tyrosine 1604.
Applications:	WB, IHC, IF
Reactivity:	Human
Immunogen:	Peptide sequence around phosphorylation site of tyrosine 1604 (G-H-Y(p)-E-D) derived from Human ALK.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Tissue Specificity:	Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
Involvement in Disease:	Neuroblastoma 3: A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system.
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Post-Translational Modification:	Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Phosphorylation at Tyr-1507 is critical for SHC1 association.
Cellular Location:	Cell membrane. Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.
Database Links:	Entrez Gene: 238?Human Omim: 105590?Human SwissProt: Q9UM73?Human Unigene: 654469?Human
Synonyms:	ALK Antibody ALK tyrosine kinase receptor Antibody ALK/EML4 fusion gene, included Antibody ALK/NPM1 fusion gene, included Antibody ALK_HUMAN Antibody Anaplastic lymphoma kinase Antibody anaplastic lymphoma kinase (Ki-1) Antibody Anaplastic lymphoma kinase Ki1 Antibody anaplastic lymphoma receptor tyrosine kinase Antibody CD 246 Antibody CD246 Antibody CD246 antigen Antibody EC 2.7.10.1 Antibody Ki 1 Antibody Ki1 Antibody mutant anaplastic lymphoma kinase Antibody NBLST 3 Antibody NBLST3 Antibody Tcrz Antibody TFG/ALK Antibody
Information:	Target information shown above is from the UniProt Consortium.