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Anti-AKR1C3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-AKR1C3 Antibody

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Overview

Name:	Anti-AKR1C3 Antibody See all AKR1C3 primary antibodies
Description:	Rabbit polyclonal antibody to AKR1C3
Specificity:	The antibody detects endogenous level of total AKR1C3 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant protein of human AKR1C3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Tissue Specificity:	Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Sequence Similarities:	Belongs to the aldo/keto reductase family.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 8644?Human Omim: 603966?Human SwissProt: P42330?Human Unigene: 78183?Human
Synonyms:	17 beta HSD 5 Antibody 17 beta hydroxysteroid dehydrogenase type 5 Antibody 17-beta-HSD 5 Antibody 17-beta-hydroxysteroid dehydrogenase type 5 Antibody 2-dihydrobenzene-1 Antibody 2-diol dehydrogenase Antibody 20-alpha-hydroxysteroid dehydrogenase Antibody 3 alpha hydroxysteroid dehydrogenase type II Antibody 3-alpha-HSD type 2 Antibody 3-alpha-HSD type II Antibody 3-alpha-HSD type II, brain Antibody 3-alpha-hydroxysteroid dehydrogenase type 2 Antibody AK1C3_HUMAN Antibody AKR1 C3 Antibody Akr1c18 Antibody AKR1C3 Antibody Aldo keto reductase family 1 member C3 Antibody Aldo-keto reductase family 1 member C3 Antibody brain Antibody Chlordecone reductase Antibody Chlordecone reductase homolog HAKRb Antibody DD-3 Antibody DD3 Antibody DDH1 Antibody DDX Antibody Dihydrodiol dehydrogenase 3 Antibody Dihydrodiol dehydrogenase type I Antibody Dihydrodiol dehydrogenase X Antibody HA1753 Antibody HAKRB Antibody HAKRe Antibody hluPGFS Antibody HSD17B5 Antibody Indanol dehydrogenase Antibody KIAA0119 Antibody PGFS Antibody Prostaglandin F synthase Antibody Testosterone 17-beta-dehydrogenase 5 Antibody Trans-1 Antibody Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Antibody Type IIb 3 alpha hydroxysteroid dehydrogenase Antibody
Information:	Target information shown above is from the UniProt Consortium.