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Anti-AIM2 Antibody

品牌：Antibodies

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规格：100µg

货期：

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Anti-AIM2 Antibody

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Name:	Anti-AIM2 Antibody See all AIM2 primary antibodies
Description:	Rabbit polyclonal antibody to AIM2
Applications:	ELISA, IHC, IP, WB
Dilutions:	DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide taken within amino acid region 240-340 on human AIM2 protein.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Concentration:	0.58 μg/μl in antibody stabilization buffer
Storage:	-20?C for long term storage

Function:	Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Tissue Specificity:	Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
Sequence Similarities:	Belongs to the HIN-200 family.
Cellular Location:	Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Database Links:	Entrez Gene: 9447?Human Entrez Gene: 383619?Mouse Omim: 604578?Human SwissProt: O14862?Human SwissProt: Q91VJ1?Mouse Unigene: 281898?Human Unigene: 733411?Human Unigene: 131453?Mouse
Synonyms:	Absent in melanoma 2 Antibody AIM 2 Antibody AIM2 Antibody AIM2_HUMAN Antibody Interferon-inducible protein AIM2 Antibody OTTHUMP00000035296 Antibody PYHIN4 Antibody
Information:	Target information shown above is from the UniProt Consortium.