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Anti-ADIPOQ Antibody

品牌：Antibodies

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规格：50µl

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Anti-ADIPOQ Antibody

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Overview

Name:	Anti-ADIPOQ Antibody See all ADIPOQ primary antibodies
Description:	Rabbit polyclonal antibody to ADIPOQ.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human ADIPOQ.
Protein Length:	244
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Tissue Specificity:	Synthesized exclusively by adipocytes and secreted into plasma.
Involvement in Disease:	Adiponectin deficiency: A condition that results in very low concentrations of plasma adiponectin. Diabetes mellitus, non-insulin-dependent: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Post-Translational Modification:	Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 9370?Human Entrez Gene: 11450?Mouse Entrez Gene: 246253?Rat Omim: 605441?Human SwissProt: Q15848?Human SwissProt: Q60994?Mouse Unigene: 80485?Human Unigene: 3969?Mouse
Synonyms:	30 kDa adipocyte complement related protein Antibody 30 kDa adipocyte complement-related protein Antibody ACDC Antibody ACRP30 Antibody Adipocyte Antibody Adipocyte C1q and collagen domain containing protein Antibody Adipocyte complement related 30 kDa protein Antibody Adipocyte complement related protein of 30 kDa Antibody Adipocyte complement-related 30 kDa protein Antibody adipocyte-specific secretory protein Antibody Adiponectin Antibody Adiponectin precursor Antibody adiponectin, C1Q and collagen domain containing Antibody Adipoq Antibody Adipose most abundant gene transcript 1 Antibody Adipose most abundant gene transcript 1 protein Antibody Adipose specific collagen like factor Antibody ADIPO_HUMAN Antibody ADIPQTL1 Antibody ADPN Antibody APM 1 Antibody apM-1 Antibody APM1 Antibody C1q and collagen domain-containing protein Antibody GBP28 Antibody Gelatin binding protein Antibody Gelatin binding protein 28 Antibody Gelatin-binding protein Antibody
Information:	Target information shown above is from the UniProt Consortium.