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Anti-ADCY 1 (D252) Antibody

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规格：50µl

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Anti-ADCY 1 (D252) Antibody

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Overview

Name:	Anti-ADCY 1 (D252) Antibody See all ADCY1 primary antibodies
Description:	Rabbit polyclonal antibody to ADCY 1 (D252)
Specificity:	ADCY 1 (D252) pAb detects endogenous levels of Adenylate cyclase type 1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 230-280 of Human ADCY 1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 130 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
Tissue Specificity:	Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla.
Involvement in Disease:	Deafness, autosomal recessive, 44: A form of non-syndromic deafness characterized by prelingual profound hearing loss affecting all frequencies.
Sequence Similarities:	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Post-Translational Modification:	N-glycosylated.
Cellular Location:	Membrane. Cell membrane. Cytoplasm. Membrane raft. Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia.
Database Links:	Entrez Gene: 107?Human Entrez Gene: 432530?Mouse Entrez Gene: 305509?Rat Omim: 103072?Human SwissProt: Q08828?Human SwissProt: O88444?Mouse Unigene: 192215?Human Unigene: 259733?Mouse Unigene: 214145?Rat
Synonyms:	Adenylate cyclase 1, fetal brain, type I Antibody 3',5'-cyclic AMP synthetase Antibody AC1 Antibody Adcy1 Antibody ADCY1_HUMAN Antibody adenyl cyclase Antibody Adenylate cyclase 1 Antibody adenylate cyclase 1 (brain) Antibody Adenylate cyclase type 1 Antibody Adenylate cyclase type I Antibody Adenylyl cyclase 1 Antibody ATP pyrophosphate lyase Antibody ATP pyrophosphate-lyase 1 Antibody Brain adenylate cyclase 1 Antibody Ca(2+)/calmodulin-activated adenylyl cyclase Antibody deafness, autosomal recessive 44 Antibody DFNB44 Antibody
Information:	Target information shown above is from the UniProt Consortium.