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Anti-ADCK3 Antibody

品牌：Antibodies

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规格：50µl

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Anti-ADCK3 Antibody

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Overview

Name:	Anti-ADCK3 Antibody See all ADCK3 primary antibodies
Description:	Rabbit polyclonal antibody to ADCK3.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human ADCK3.
Protein Length:	647
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).
Tissue Specificity:	Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle.
Involvement in Disease:	Coenzyme Q10 deficiency, primary, 4: An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures.
Sequence Similarities:	Belongs to the protein kinase superfamily. ADCK protein kinase family.
Cellular Location:	Mitochondrion. Membrane.
Database Links:	Entrez Gene: 56997?Human Entrez Gene: 67426?Mouse Omim: 606980?Human SwissProt: Q8NI60?Human SwissProt: Q60936?Mouse Unigene: 118241?Human Unigene: 38330?Mouse
Synonyms:	aarF domain containing protein kinase 3 Antibody aarF domain-containing protein kinase 3 Antibody ADCK 3 Antibody ADCK3 Antibody ADCK3_HUMAN Antibody ARCA2 Antibody CABC 1 Antibody CABC1 Antibody Chaperone ABC1 (activity of bc1 complex S.pombe) like Antibody Chaperone ABC1 activity of bc1 complex homolog Antibody Chaperone ABC1 like Antibody Chaperone activity of bc1 complex like Antibody Chaperone activity of bc1 complex like mitochondrial Antibody Chaperone activity of bc1 complex-like Antibody Chaperone-ABC1-like Antibody Coenzyme Q8 homolog Antibody COQ 8 Antibody COQ10D4 Antibody COQ8 Antibody COQ8, S. cerevisiae, homolog of Antibody MGC4849 Antibody mitochondrial Antibody OTTHUMP00000035734 Antibody OTTHUMP00000035737 Antibody SCAR9 Antibody
Information:	Target information shown above is from the UniProt Consortium.