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Anti-Active Caspase-3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Active Caspase-3 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-Active Caspase-3 Antibody See all Active Caspase-3 primary antibodies
Description:	Rabbit monoclonal antibody to Active Caspase-3.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human
Immunogen:	Recombinant protein of human CASP3.
Host:	Rabbit
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Tissue Specificity:	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 836?Human Omim: 600636?Human SwissProt: P42574?Human Unigene: 141125?Human
Synonyms:	active Caspase-3 Antibody Apopain Antibody CASP 3 Antibody CASP-3 Antibody CASP3 Antibody CASP3_HUMAN Antibody Caspase 3 Antibody Caspase-3 subunit p12 Antibody cleaved caspase 3 Antibody CPP 32 Antibody CPP-32 Antibody CPP32B Antibody Cysteine protease CPP32 Antibody PARP cleavage protease Antibody Protein Yama Antibody SCA-1 Antibody SCA1 Antibody SREBP cleavage activity 1 Antibody Yama Antibody
Information:	Target information shown above is from the UniProt Consortium.