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Anti-ABCG2 (N338) Antibody

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规格：50µl

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Anti-ABCG2 (N338) Antibody

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Overview

Name:	Anti-ABCG2 (N338) Antibody See all ABCG2 primary antibodies
Description:	Rabbit polyclonal antibody to ABCG2 (N338)
Specificity:	ABCG2 (N338) pAb detects endogenous levels of ATP-binding cassette sub-family G member 2 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 302-356 of Human ABCG2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 72 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Tissue Specificity:	Highly expressed in placenta. Low expression in small intestine, liver and colon.
Sequence Similarities:	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Post-Translational Modification:	Glycosylation-deficient ABCG2 is normally expressed and functional.
Cellular Location:	Cell membrane. Mitochondrion membrane.
Database Links:	Entrez Gene: 9429?Human Entrez Gene: 26357?Mouse Entrez Gene: 312382?Rat Omim: 603756?Human SwissProt: Q9UNQ0?Human SwissProt: Q7TMS5?Mouse SwissProt: Q80W57?Rat Unigene: 480218?Human Unigene: 333096?Mouse Unigene: 13131?Rat
Synonyms:	ABC transporter Antibody ABC15 Antibody ABCG 2 Antibody ABCG2 Antibody ABCG2_HUMAN Antibody ABCP Antibody ATP binding cassette sub family G (WHITE) member 2 Antibody ATP binding cassette transporter G2 Antibody ATP-binding cassette sub-family G member 2 Antibody BCRP Antibody BCRP/ABCG2 Antibody BCRP1 Antibody BMDP Antibody Breast cancer resistance protein Antibody CD338 Antibody CDw338 Antibody CDw338 antigen Antibody EST157481 Antibody GOUT1 Antibody MGC102821 Antibody Mitoxantrone resistance associated protein Antibody Mitoxantrone resistance-associated protein Antibody MRX Antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 Antibody MXR Antibody MXR1 Antibody Placenta specific ATP binding cassette transporter Antibody Placenta specific MDR protein Antibody Placenta-specific ATP-binding cassette transporter Antibody UAQTL1 Antibody
Information:	Target information shown above is from the UniProt Consortium.