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Anti-STAT4 Antibody

品牌：Antibodies

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规格：50µl

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Anti-STAT4 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-STAT4 Antibody See all STAT4 primary antibodies
Description:	Rabbit polyclonal antibody to STAT4.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human STAT4.
Protein Length:	748
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Involvement in Disease:	Systemic lupus erythematosus 11: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Sequence Similarities:	Belongs to the transcription factor STAT family.
Post-Translational Modification:	Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
Cellular Location:	Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Database Links:	Entrez Gene: 6775?Human Entrez Gene: 20849?Mouse Entrez Gene: 367264?Rat Omim: 600558?Human SwissProt: Q14765?Human SwissProt: P42228?Mouse Unigene: 735572?Human Unigene: 80642?Human Unigene: 1550?Mouse
Synonyms:	Signal transducer and activator of transcription 4 Antibody SLEB11 Antibody STAT4 Antibody STAT4_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.