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Anti-SPARC Antibody

品牌：Antibodies

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规格：50µl

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Anti-SPARC Antibody

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Overview

Name:	Anti-SPARC Antibody See all SPARC primary antibodies
Description:	Rabbit polyclonal antibody to SPARC.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SPARC.
Protein Length:	303
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium s; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Involvement in Disease:	Osteogenesis imperfecta 17: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae.
Sequence Similarities:	Belongs to the SPARC family.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix > Basement membrane. In or around the basement membrane.
Database Links:	Entrez Gene: 6678?Human Entrez Gene: 20692?Mouse Entrez Gene: 24791?Rat Omim: 182120?Human SwissProt: P09486?Human SwissProt: P07214?Mouse SwissProt: P16975?Rat Unigene: 111779?Human Unigene: 708558?Human Unigene: 291442?Mouse Unigene: 98989?Rat
Synonyms:	AA517111 Antibody Basement membrane protein 40 Antibody Basement-membrane protein 40 Antibody BM 40 Antibody BM-40 Antibody BM40 Antibody Cysteine rich protein Antibody hm:zeh0062 Antibody MGC128090 Antibody OI17 Antibody ON Antibody Osteonectin Antibody Secreted acidic cystein rich glycoprotein Antibody Secreted protein acidic and cysteine rich Antibody Secreted protein acidic and rich in cysteine Antibody Secreted protein acidic cysteine rich Antibody Secreted protein acidic cysteine rich (osteonectin) Antibody SPARC Antibody SPRC Antibody SPRC_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.