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Anti-PRMT5 Antibody

品牌：Antibodies

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规格：50µl

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Anti-PRMT5 Antibody

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Overview

Name:	Anti-PRMT5 Antibody See all PRMT5 primary antibodies
Description:	Mouse monoclonal antibody to PRMT5
Specificity:	This antibody detects endogenous levels of PRMT5 and does not cross-react with related proteins.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to a region of PRMT5.
Host:	Mouse
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 70 kDa
Purity:	Protein A affinity purified
Product Form:	Mouse IgG2a. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805).
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Cellular Location:	Cytoplasm. Nucleus. Golgi apparatus.
Database Links:	Entrez Gene: 10419?Human Entrez Gene: 27374?Mouse Entrez Gene: 364382?Rat Omim: 604045?Human SwissProt: O14744?Human SwissProt: Q8CIG8?Mouse Unigene: 367854?Human Unigene: 196585?Mouse Unigene: 101808?Rat
Synonyms:	72 kDa ICln binding protein Antibody 72 kDa ICln-binding protein Antibody ANM5_HUMAN Antibody Histone synthetic lethal 7, S. cerevisiae, homolog of Antibody Histone-arginine N-methyltransferase PRMT5 Antibody HMT1 hnRNP methyltransferase like 5 Antibody HOMOLOG OF; SKB1 Antibody HRMT1L5 Antibody IBP72 Antibody Jak-binding protein 1 Antibody JBP 1 Antibody JBP1 Antibody PRMT 5 Antibody PRMT5 Antibody Protein arginine methyltransferase 5 Antibody Protein arginine N methyltransferase 5 Antibody Protein arginine N methyltransferase 5 N terminally processed Antibody Protein arginine N-methyltransferase 5 Antibody S. POMBE Antibody S. POMBE HOMOLOG OF; SKB1 Antibody SHK1 KINASE BINDING PROTEIN 1 Antibody Shk1 kinase binding protein 1 homolog Antibody Shk1 kinase-binding protein 1 homolog Antibody Shk1 kinase/binding protein 1, S. pombe, homolog of Antibody SKB 1 Antibody SKB1 Antibody SKB1 homolog Antibody SKB1: SKB1 homolog (S. pombe) Antibody SKB1Hs Antibody
Information:	Target information shown above is from the UniProt Consortium.