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Anti-PNKP Antibody

品牌：Antibodies

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规格：50µl

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Anti-PNKP Antibody

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Overview

Name:	Anti-PNKP Antibody See all PNKP primary antibodies
Description:	Rabbit polyclonal antibody to PNKP.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Rat
Immunogen:	Recombinant protein of human PNKP.
Protein Length:	521
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Tissue Specificity:	Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193).
Involvement in Disease:	Microcephaly, seizures, and developmental delay: A disease characterized by infantile-onset seizures, microcephaly, severe intellectual disability and delayed motor milestones with absent speech or only achieving a few words. Most patients also have behavioral problems with hyperactivity. Microcephaly is progressive and without neuronal migration or structural abnormalities, consistent with primary microcephaly. Ataxia-oculomotor apraxia 4: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.
Sequence Similarities:	In the N-terminal section; belongs to the DNA 3' phosphatase family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 11284?Human Omim: 605610?Human SwissProt: Q96T60?Human Unigene: 78016?Human
Synonyms:	2''(3'')-polynucleotidase Antibody 2'(3')-polynucleotidase Antibody Bifunctional polynucleotide phosphatase/kinase Antibody DEM 1 Antibody DEM1 Antibody DNA 5' kinase/3' phosphatase Antibody DNA 5''-kinase/3''-phosphatase Antibody EIEE10 Antibody Homo sapiens polynucleotide kinase 3' phosphatase (PNKP) Antibody MCSZ Antibody PNK Antibody PNK 1 Antibody PNK1 Antibody Pnkp Antibody PNKP DNA kinase Antibody PNKP_HUMAN Antibody Polynucleotide 3'-phosphatase Antibody Polynucleotide 5' hydroxyl kinase Antibody Polynucleotide 5''-hydroxyl-kinase Antibody Polynucleotide Kinase Antibody Polynucleotide kinase 3 prime phosphatase Antibody Polynucleotide kinase 3' phosphatase Antibody Polynucleotide kinase-3''-phosphatase Antibody
Information:	Target information shown above is from the UniProt Consortium.