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Anti-PARP Antibody

品牌：Antibodies

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规格：50µl

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Anti-PARP Antibody

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Overview

Name:	Anti-PARP Antibody See all PARP primary antibodies
Description:	Rabbit polyclonal antibody to PARP
Specificity:	PARP pAb detects endogenous levels of full length PARP1 (116 kDa), as well as the large fragment (89 kDa) of PARP1 resulting from caspase cleavage.
Applications:	WB
Reactivity:	Human, Mouse
Immunogen:	Recombinant full length Human PARP.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 89, 116 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Post-Translational Modification:	Phosphorylated by PRKDC and TXK.
Cellular Location:	Nucleus. Nucleus > Nucleolus. Localizes at sites of DNA damage.
Database Links:	Entrez Gene: 142 Human Entrez Gene: 11545 Mouse Omim: 173870 Human SwissProt: P09874 Human SwissProt: P11103 Mouse Unigene: 177766 Human Unigene: 277779 Mouse
Synonyms:	ADP ribosyltransferase Antibody ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) Antibody ADP ribosyltransferase diphtheria toxin like 1 Antibody ADP ribosyltransferase NAD(+) Antibody ADPRT Antibody ADPRT 1 Antibody ADPRT1 Antibody ARTD1 Antibody msPARP Antibody NAD(+) ADP ribosyltransferase 1 Antibody NAD(+) ADP-ribosyltransferase 1 Antibody pADPRT 1 Antibody pADPRT1 Antibody PARP Antibody PARP 1 Antibody PARP-1 Antibody PARP1 Antibody PARP1_HUMAN Antibody Poly (ADP ribose) polymerase 1 Antibody poly (ADP ribose) polymerase family, member 1 Antibody Poly [ADP-ribose] polymerase 1 Antibody Poly(ADP ribose) polymerase Antibody poly(ADP ribose) synthetase Antibody poly(ADP ribosyl)transferase Antibody Poly[ADP ribose] synthetase 1 Antibody Poly[ADP-ribose] synthase 1 Antibody PPOL Antibody
Information:	Target information shown above is from the UniProt Consortium.