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Anti-NELFE Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-NELFE Antibody

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Name:	Anti-NELFE Antibody See all NELFE primary antibodies
Description:	Rabbit polyclonal antibody to NELFE.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse
Immunogen:	Recombinant protein of human NELFE.
Protein Length:	380
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activty of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.
Tissue Specificity:	Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
Sequence Similarities:	Belongs to the RRM NELF-E family.
Post-Translational Modification:	Sumoylated.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 7936?Human Entrez Gene: 27632?Mouse Omim: 154040?Human SwissProt: P18615?Human SwissProt: P19426?Mouse Unigene: 423935?Human Unigene: 279907?Mouse Unigene: 653?Mouse
Synonyms:	Major histocompatibility complex gene RD Antibody Negative elongation factor E Antibody Negative elongation factor polypeptide E Antibody NELF e Antibody NELF-E Antibody NELFe Antibody NELFE_HUMAN Antibody Nuclear protein Antibody RD Antibody RD protein Antibody RD RNA binding protein Antibody RDP Antibody RNA-binding protein RD Antibody
Information:	Target information shown above is from the UniProt Consortium.