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Anti-MMP14 Antibody

品牌：Antibodies

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规格：50µl

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Anti-MMP14 Antibody

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Overview

Name:	Anti-MMP14 Antibody See all MMP14 primary antibodies
Description:	Rabbit monoclonal antibody to MMP14
Specificity:	This antibody detects endogenous levels of MMP14 and does not cross-react with related proteins.
Applications:	WB, ICC/IF, IHC, FC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 65 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.
Tissue Specificity:	Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
Involvement in Disease:	Winchester syndrome: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes.
Sequence Similarities:	Belongs to the peptidase M10A family.
Post-Translational Modification:	The precursor is cleaved by a furin endopeptidase.
Cellular Location:	Membrane. Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
Database Links:	Entrez Gene: 4323?Human Entrez Gene: 17387?Mouse Entrez Gene: 81707?Rat Omim: 600754?Human SwissProt: P50281?Human SwissProt: P53690?Mouse SwissProt: Q10739?Rat Unigene: 2399?Human Unigene: 280175?Mouse Unigene: 10371?Rat
Synonyms:	Matrix metallopeptidase 14 (membrane inserted) Antibody Matrix metalloproteinase 14 Antibody Matrix metalloproteinase-14 Antibody Membrane type 1 matrix metalloproteinase Antibody Membrane type 1 metalloprotease Antibody Membrane type matrix metalloproteinase 1 Antibody Membrane-type matrix metalloproteinase 1 Antibody Membrane-type-1 matrix metalloproteinase Antibody MMP 14 Antibody MMP X1 Antibody MMP-14 Antibody MMP-X1 Antibody MMP14 Antibody MMP14_HUMAN Antibody MMPX1 Antibody MT MMP Antibody MT MMP 1 Antibody MT-MMP 1 Antibody MT1 MMP Antibody MT1-MMP Antibody MT1MMP Antibody MTMMP 1 Antibody MTMMP1 Antibody WNCHRS Antibody
Information:	Target information shown above is from the UniProt Consortium.