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Anti-LRP6 Antibody

品牌：Antibodies

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规格：100µg

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Anti-LRP6 Antibody

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Overview

Name:	Anti-LRP6 Antibody See all LRP6 primary antibodies
Description:	Goat polyclonal antibody to LRP6.
Applications:	ELISA, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human LRP6 (internal region).
Sequence:	CMTSVATAKGYTSDL
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Tissue Specificity:	Widely coexpressed with LRP5 during embryogenesis and in ***** tissues.
Involvement in Disease:	Coronary artery disease, autosomal dominant, 2: A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction. Tooth agenesis, selective, 7: An autosomal dominant form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).
Sequence Similarities:	Belongs to the LDLR family.
Post-Translational Modification:	Dual phosphorylation of cytoplasmic PPPSP motifs sequentially by GSK3 and CK1 is required for AXIN1-binding, and subsequent stabilization and activation of beta-catenin via preventing GSK3-mediated phosphorylation of beta-catenin. Phosphorylated, in vitro, by GRK5/6 within and outside the PPPSP motifs. Phosphorylation at Ser-1490 by CDK14 during G2/M phase leads to regulation of the Wnt signaling pathway during the cell cycle. Phosphorylation by GSK3B is induced by RPSO1 binding and inhibited by DKK1. Phosphorylated, in vitro, by casein kinase I on Thr-1479.
Cellular Location:	Cell membrane. Endoplasmic reticulum. Membrane raft. On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity).
Database Links:	Entrez Gene: 4040?Human Omim: 603507?Human SwissProt: O75581?Human Unigene: 584775?Human Unigene: 658913?Human
Synonyms:	ADCAD2 Antibody C030016K15Rik Antibody Cd Antibody FLJ90062 Antibody FLJ90421 Antibody LDL receptor related protein 6 Antibody Low density lipoprotein receptor related protein 6 Antibody Low-density lipoprotein receptor-related protein 6 Antibody LRP-6 Antibody LRP6 Antibody LRP6_HUMAN Antibody OTTHUMP00000238979 Antibody OTTHUMP00000238980 Antibody OTTHUMP00000238982 Antibody STHAG7 Antibody
Information:	Target information shown above is from the UniProt Consortium.