| Function: |
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820). |
| Tissue Specificity: |
Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698). |
| Involvement in Disease: |
Danon disease: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. |
| Sequence Similarities: |
Belongs to the LAMP family. |
| Post-Translational Modification: |
O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans. |
| Cellular Location: |
Cell membrane. Endosome membrane. Lysosome membrane. Cytoplasmic vesicle > Autophagosome membrane.
This protein shuttles between lysosomes, endosomes, and the plasma membrane. |
| Database Links: |
Entrez Gene: 3920?HumanEntrez Gene: 16784?MouseOmim: 309060?HumanSwissProt: P13473?HumanSwissProt: P17047?MouseSwissProt: P17046?RatUnigene: 496684?HumanUnigene: 414016?MouseUnigene: 486?MouseUnigene: 1722?Rat |
| Synonyms: |
CD107 antigen-like family member B AntibodyCD107b AntibodyLAMP 2 AntibodyLamp 2a AntibodyLAMP-2 AntibodyLAMP2 AntibodyLAMP2A AntibodyLAMP2_HUMAN AntibodyLysosome-associated membrane glycoprotein 2 AntibodyLysosome-associated membrane protein 2 Antibody |
| Information: |
Target information shown above is from the UniProt Consortium. |
