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Anti-UHRF2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-UHRF2 Antibody

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Overview

Name:	Anti-UHRF2 Antibody See all UHRF2 primary antibodies
Description:	Rabbit polyclonal antibody to UHRF2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:50.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human UHRF2.
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
Post-Translational Modification:	May be autoubiquitinated; which may lead to proteasomal degradation.
Cellular Location:	Nucleus. Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity).
Database Links:	Entrez Gene: 115426?Human Entrez Gene: 109113?Mouse Entrez Gene: 309331?Rat SwissProt: Q96PU4?Human SwissProt: Q7TMI3?Mouse Unigene: 493401?Human Unigene: 313364?Mouse
Synonyms:	DKFZp434B0920 Antibody DKFZp686G0837 Antibody E3 ubiquitin-protein ligase UHRF2 Antibody MGC33463 Antibody NIRF Antibody Np95 like RING finger protein Antibody Np95-like ring finger protein Antibody Np95/ICBP90 like RING finger protein Antibody Np95/ICBP90-like RING finger protein Antibody Nuclear protein 97 Antibody Nuclear zinc finger protein Np97 Antibody RING finger protein 107 Antibody RNF 107 Antibody RP11-472F14.2 Antibody Ubiquitin like containing PHD and RING finger domains protein 2 Antibody Ubiquitin-like PHD and RING finger domain-containing protein 2 Antibody Ubiquitin-like-containing PHD and RING finger domains protein 2 Antibody Uhrf2 Antibody UHRF2_HUMAN Antibody URF 2 Antibody
Information:	Target information shown above is from the UniProt Consortium.