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Anti-TOLLIP Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

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Anti-TOLLIP Antibody

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Name:	Anti-TOLLIP Antibody See all TOLLIP primary antibodies
Description:	Rabbit polyclonal antibody to TOLLIP.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human TOLLIP.
Protein Length:	274
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
Sequence Similarities:	Belongs to the tollip family.
Post-Translational Modification:	Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 54472?Human Entrez Gene: 54473?Mouse Entrez Gene: 361677?Rat Omim: 606277?Human SwissProt: Q9H0E2?Human SwissProt: Q9QZ06?Mouse SwissProt: A2RUW1?Rat Unigene: 368527?Human Unigene: 103551?Mouse Unigene: 137040?Rat
Synonyms:	Adapter protein Antibody FLJ33531 Antibody IL 1RAcPIP Antibody IL1RAcPIP Antibody TOLIP Antibody TOLIP_HUMAN Antibody Toll interacting protein Antibody Toll-interacting protein Antibody Tollip Antibody
Information:	Target information shown above is from the UniProt Consortium.