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Anti-TNNC1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-TNNC1 Antibody

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Overview

Name:	Anti-TNNC1 Antibody See all TNNC1 primary antibodies
Description:	Rabbit polyclonal antibody to TNNC1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human TNNC1.
Protein Length:	161
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Involvement in Disease:	Cardiomyopathy, dilated 1Z: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Cardiomyopathy, familial hypertrophic 13: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Sequence Similarities:	Belongs to the troponin C family.
Database Links:	Entrez Gene: 7134?Human Entrez Gene: 21924?Mouse Entrez Gene: 290561?Rat Omim: 191040?Human SwissProt: P63316?Human SwissProt: P19123?Mouse Unigene: 118845?Human Unigene: 439921?Mouse Unigene: 15460?Rat
Synonyms:	Cardiac troponin C Antibody CMD1Z Antibody CMH13 Antibody slow skeletal and cardiac muscles Antibody Slow twitch skeletal/cardiac muscle troponin C Antibody TN-C Antibody TNC Antibody TNNC Antibody TNNC1 Antibody TNNC1 troponin C type 1 (slow) Antibody TNNC1_HUMAN Antibody Troponin C Antibody troponin C type 1 (slow) Antibody Troponin C, slow skeletal and cardiac muscles Antibody Troponin C1, slow Antibody
Information:	Target information shown above is from the UniProt Consortium.