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Anti-Mcl-1 (S121) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Mcl-1 (S121) Antibody

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Overview

Name:	Anti-Mcl-1 (S121) Antibody See all Mcl1 primary antibodies
Description:	Rabbit polyclonal antibody to Mcl-1 (S121)
Specificity:	MCL1 (S121) pAb detects endogenous levels of MCL1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 100-150 of Human Mcl-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 37 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Sequence Similarities:	Belongs to the Bcl-2 family.
Post-Translational Modification:	Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Cellular Location:	Membrane. Cytoplasm. Mitochondrion. Nucleus > Nucleoplasm. Cytoplasmic, associated with mitochondria.
Database Links:	Entrez Gene: 4170?Human Entrez Gene: 17210?Mouse Entrez Gene: 60430?Rat Omim: 159552?Human SwissProt: Q07820?Human SwissProt: P97287?Mouse SwissProt: Q9Z1P3?Rat Unigene: 632486?Human Unigene: 1639?Mouse Unigene: 161889?Rat
Synonyms:	Bcl 2 related protein EAT/mcl1 Antibody Bcl-2-like protein 3 Antibody Bcl-2-related protein EAT/mcl1 Antibody BCL2 related Antibody Bcl2-L-3 Antibody BCL2L3 Antibody EAT Antibody Induced myeloid leukemia cell differentiation protein Mcl 1 Antibody Induced myeloid leukemia cell differentiation protein Mcl-1 Antibody MCL 1 Antibody MCL1 Antibody MCL1-ES Antibody mcl1/EAT Antibody MCL1L Antibody MCL1S Antibody MCL1_HUMAN Antibody MGC104264 Antibody MGC1839 Antibody Myeloid Cell Leukemia 1 Antibody Myeloid cell leukemia ES Antibody Myeloid cell leukemia sequence 1 Antibody Myeloid cell leukemia sequence 1 BCL2 related Antibody Myeloid cell leukemia sequence 1 isoform 1 Antibody OTTHUMP00000032794 Antibody OTTHUMP00000032795 Antibody TM Antibody
Information:	Target information shown above is from the UniProt Consortium.