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Anti-MAP1LC3A Antibody

品牌：Antibodies

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规格：50µl

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Anti-MAP1LC3A Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-MAP1LC3A Antibody See all MAP1LC3A primary antibodies
Description:	Rabbit monoclonal antibody to MAP1LC3A
Specificity:	This antibody detects endogenous levels of MAP1LC3A and does not cross-react with related proteins.
Applications:	WB, ICC/IF, IHC, FC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 14 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).
Tissue Specificity:	Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
Sequence Similarities:	Belongs to the ATG8 family.
Post-Translational Modification:	The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).
Cellular Location:	Cytoplasm > Cytoskeleton. Endomembrane system. Cytoplasmic vesicle > Autophagosome membrane. Cytoplasmic vesicle > Autophagosome. LC3-II binds to the autophagic membranes.
Database Links:	Entrez Gene: 84557?Human Entrez Gene: 66734?Mouse Entrez Gene: 362245?Rat Omim: 601242?Human SwissProt: Q9H492?Human SwissProt: Q91VR7?Mouse SwissProt: Q6XVN8?Rat Unigene: 632273?Human Unigene: 196239?Mouse Unigene: 3135?Rat
Synonyms:	ATG8E Antibody Autophagy-related protein LC3 A Antibody Autophagy-related ubiquitin-like modifier LC3 A Antibody LC3 Antibody LC3A Antibody MAP1 light chain 3 like protein 1 Antibody MAP1 light chain 3-like protein 1 Antibody MAP1A/1B light chain 3 A Antibody MAP1A/MAP1B LC3 A Antibody MAP1A/MAP1B light chain 3 A Antibody MAP1ALC3 Antibody MAP1BLC3 Antibody MAP1LC3A Antibody Microtubule associated proteins 1A/1B light chain 3 Antibody Microtubule-associated protein 1 light chain 3 alpha Antibody Microtubule-associated proteins 1A and 1B, light chain 3 Antibody Microtubule-associated proteins 1A/1B light chain 3A Antibody MLP3A_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.