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Anti-GEMIN2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-GEMIN2 Antibody

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Overview

Name:	Anti-GEMIN2 Antibody See all GEMIN2 primary antibodies
Description:	Rabbit polyclonal antibody to GEMIN2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:1000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide of human GEMIN2.
Protein Length:	280
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Sequence Similarities:	Belongs to the gemin-2 family.
Cellular Location:	Nucleus > Gem. Cytoplasm. Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
Database Links:	Entrez Gene: 8487?Human Entrez Gene: 66603?Mouse Entrez Gene: 84404?Rat Omim: 602595?Human SwissProt: O14893?Human SwissProt: Q9CQQ4?Mouse SwissProt: Q9QZP1?Rat Unigene: 652307?Human Unigene: 35353?Mouse Unigene: 34143?Rat
Synonyms:	Component of gems 2 Antibody Gem (nuclear organelle) associated protein 2 Antibody Gem associated protein 2 Antibody GEMI2_HUMAN Antibody Gemin 2 Antibody Gemin-2 Antibody gemin2 Antibody SIP 1 Antibody SIP-1 Antibody SIP1 Antibody SIP1 delta Antibody SIP1-delta Antibody SMN interacting protein 1 Antibody SMN interacting protein 1 delta Antibody SMN-interacting protein 1 Antibody Survival interacting protein 1 Antibody Survival of motor neuron protein interacting protein 1 Antibody Survival of motor neuron protein-interacting protein 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.