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Anti-DDX1 Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-DDX1 Antibody

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Overview

Name:	Anti-DDX1 Antibody See all DDX1 primary antibodies
Description:	Rabbit polyclonal antibody to DDX1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human DDX1.
Protein Length:	740
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Required for HIV-1 Rev function as well as for HIV-1 replication. Binds to the RRE sequence of HIV-1 mRNAs.
Tissue Specificity:	Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord.
Sequence Similarities:	Belongs to the DEAD box helicase family. DDX1 subfamily.
Post-Translational Modification:	Phosphorylated. Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR).
Cellular Location:	Nucleus. Cytoplasm. Cytoplasmic granule. Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells. Required for proper localization of HIV-1 Rev. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).
Database Links:	Entrez Gene: 1653?Human Entrez Gene: 104721?Mouse Entrez Gene: 84474?Rat Omim: 601257?Human SwissProt: Q92499?Human SwissProt: Q91VR5?Mouse SwissProt: Q641Y8?Rat Unigene: 440599?Human Unigene: 251255?Mouse Unigene: 65536?Rat
Synonyms:	ATP dependent helicase DDX1 Antibody ATP-dependent RNA helicase DDX1 Antibody DBP RB Antibody DBP-RB Antibody DDX1 Antibody DDX1_HUMAN Antibody DEAD (Asp Glu Ala Asp) box polypeptide 1 Antibody DEAD box 1 Antibody DEAD box polypeptide 1 Antibody DEAD box protein 1 Antibody DEAD box protein retinoblastoma Antibody DEAD/H (Asp Glu Ala Asp/His) box polypeptide 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.