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Anti-Cdc20 (Q105) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Cdc20 (Q105) Antibody

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Overview

Name:	Anti-Cdc20 (Q105) Antibody See all Cdc20 primary antibodies
Description:	Rabbit polyclonal antibody to Cdc20 (Q105)
Specificity:	Cdc20 (Q105) pAb detects endogenous levels of Cdc20 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 80-130 of Human Cdc20.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 55 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Sequence Similarities:	Belongs to the WD repeat CDC20/Fizzy family.
Post-Translational Modification:	Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
Cellular Location:	Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle pole.
Database Links:	Entrez Gene: 991?Human Entrez Gene: 107995?Mouse Entrez Gene: 64515?Rat Omim: 603618?Human SwissProt: Q12834?Human SwissProt: Q9JJ66?Mouse SwissProt: Q62623?Rat Unigene: 524947?Human Unigene: 289747?Mouse Unigene: 9262?Rat
Synonyms:	bA276H19.3 Antibody Cdc 20 Antibody Cdc20 Antibody CDC20 cell division cycle 20 homolog Antibody CDC20A Antibody CDC20_HUMAN Antibody Cell division cycle 20 Antibody Cell division cycle 20 homolog Antibody Cell division cycle 20 homolog (S. cerevisiae) Antibody Cell division cycle protein 20 homolog Antibody fizzy Antibody MGC102824 Antibody p55CDC Antibody
Information:	Target information shown above is from the UniProt Consortium.