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Anti-CD41 Antibody

品牌：Antibodies

货号：

规格：100µg

货期：

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Anti-CD41 Antibody

商品详情参考文献相关资料

Name:	Anti-CD41 Antibody See all CD41 primary antibodies
Description:	Rat monoclonal (MWReg30) antibody to CD41.
Specificity:	The rat monoclonal antibody MWReg30 recognizes CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Applications:	FC, IP, IHC-P, IHC-Fr, ELISA, FUNC
Reactivity:	Mouse
Immunogen:	Murine platelets.
Host:	Rat
Clonality:	Monoclonal
Clone:	MWReg30
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein G chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage:	Store at 2-8°C.

Function:	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Sequence Similarities:	Belongs to the integrin alpha chain family.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 16399?Mouse SwissProt: Q9QUM0?Mouse Unigene: 26646?Mouse
Synonyms:	antigen CD41 Antibody BDPLT16 Antibody BDPLT2 Antibody CD41 Antibody CD41B Antibody form 2 Antibody GP2B Antibody GPalpha IIb Antibody GPIIb Antibody GT Antibody GTA Antibody HPA3 Antibody Integrin alpha 2b Antibody Integrin alpha IIb Antibody Integrin alpha-IIb light chain Antibody Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Antibody ITA2B_HUMAN Antibody Itga2b Antibody ITGAB Antibody platelet fibrinogen receptor, alpha subunit Antibody platelet glycoprotein IIb of IIb/IIIa complex Antibody Platelet membrane glycoprotein IIb Antibody platelet specific antigen BAK Antibody PPP1R93 Antibody
Information:	Target information shown above is from the UniProt Consortium.