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Anti-ASH2L Antibody

品牌：Antibodies

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规格：100µl

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Anti-ASH2L Antibody

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Overview

Name:	Anti-ASH2L Antibody See all ASH2L primary antibodies
Description:	Rabbit monoclonal antibody to ASH2L.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human ASH2L.
Host:	Rabbit
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
Tissue Specificity:	Ubiquitously expressed. Predominantly expressed in *** heart and testis and fetal lung and liver, with barely detectable expression in *** lung, liver, kidney, prostate, and peripheral leukocytes.
Post-Translational Modification:	Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 9070?Human Entrez Gene: 23808?Mouse Entrez Gene: 290829?Rat Omim: 604782?Human SwissProt: Q9UBL3?Human SwissProt: Q91X20?Mouse Unigene: 521530?Human Unigene: 27706?Mouse Unigene: 219095?Rat
Synonyms:	ASH 2 Antibody ASH2 Antibody Ash2 (absent small or homeotic) like Antibody Ash2 (absent, small, or homeotic) like (Drosophila) Antibody ASH2 LIKE Antibody ASH2 like protein Antibody ASH2-like protein Antibody ASH2L Antibody ASH2L1 Antibody ASH2L2 Antibody ASH2L_HUMAN Antibody Bre 2 Antibody Bre2 Antibody Discs 2-like Antibody Drosophila absent, small, or homeotic Antibody Drosophila ASH2-like Antibody Set1/Ash2 histone methyltransferase complex subunit ASH2 Antibody
Information:	Target information shown above is from the UniProt Consortium.