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Anti-ADAM17 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-ADAM17 Antibody

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Overview

Name:	Anti-ADAM17 Antibody See all ADAM17 primary antibodies
Description:	Goat polyclonal antibody to ADAM17.
Applications:	ELISA, WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human ADAM17 (C terminal).
Sequence:	LQRQNRVDSKETEC
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Tissue Specificity:	Ubiquitously expressed. Expressed at highest levels in ***** heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Involvement in Disease:	Inflammatory skin and bowel disease, neonatal, 1: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.
Post-Translational Modification:	The precursor is cleaved by a furin endopeptidase.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 6868?Human Omim: 603639?Human SwissProt: P78536?Human Unigene: 404914?Human
Synonyms:	A disintegrin and metalloproteinase domain 17 Antibody A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) Antibody ADA17_HUMAN Antibody ADAM 17 Antibody ADAM metallopeptidase domain 17 Antibody ADAM17 Antibody ADAM17 protein Antibody CD 156b Antibody CD156b Antibody CD156b antigen Antibody CSVP Antibody Disintegrin and metalloproteinase domain-containing protein 17 Antibody MGC71942 Antibody NISBD Antibody NISBD1 Antibody Snake venom like protease Antibody Snake venom-like protease Antibody TACE Antibody TNF alpha convertase Antibody TNF alpha converting enzyme Antibody TNF-alpha convertase Antibody TNF-alpha-converting enzyme Antibody Tumor Necrosis Factor Alpha Converting Enzyme Antibody
Information:	Target information shown above is from the UniProt Consortium.